NMDAR LTP and LTD induction: 2B or Not 2B...is that the question?

Frail or not? That is the question.

Synaptic plasticity: LTP and LTD.

Long-term potentiation (LTP) is a synaptic enhancement that follows brief, high-frequency electrical stimulation in the hippocampus and neocortex. Recent evidence suggests that induction of LTP may require, in addition to postsynaptic Ca2+ entry, activation of metabotropic glutamate receptors and the generation of diffusible intercellular messengers. A new form of synaptic plasticity, homosynap...

coeliac disease: to classify or not to classify – that is the question!

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The Return of the Spike Postsynaptic Action Potentials and the Induction of LTP and LTD

mark where postsynaptic spiking was concerned. Perhaps the most quoted idea in the history of neurosci-The Last Laugh ence is the synaptic modification postulate proposed Recently, an exciting set of experiments have caused by the Canadian psychologist Donald Hebb in his 1949 renewed interest in postsynaptic spiking and synaptic book, The Organization of Behavior. Formulated to ex-plasticity an...

Needed to Trigger LTD and LTP

aptic [Ca]i (Dunwiddie and Lynch, 1978; Dudek and Long-term potentiation (LTP) and long-term depresBear, 1992); afferent stimulation that generates LTP can sion (LTD) in CA1 pyramidal neuronsare both triggered generate LTD when postsynaptic neurons are less depoby a postsynaptic rise in intracellular Ca21 concentralarized, when extracellular [Mg] is elevated or NMDA tion ([Ca]i). We used photol...